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P1–174: Quantitative mass spectrometry (SRM/MRM) for amyloid peptides, tau protein and apolipoprotein E in human cerebrospinal fluid for Alzheimer's disease diagnosis
Author(s) -
Lehmann Sylvain,
Barthelemy Nicolas,
Vialaret Jerome,
SchraenMaschke Susanna,
Tiers Laurent,
Delaby Constance,
Becher François,
Touchon Jacques,
Junot Christophe,
Hirtz Christophe,
Gabelle Audrey
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.397
Subject(s) - chemistry , selected reaction monitoring , cerebrospinal fluid , mass spectrometry , gene isoform , apolipoprotein e , alzheimer's disease , chromatography , computational biology , biochemistry , tandem mass spectrometry , disease , biology , pathology , medicine , gene
RR intervals(SDNN) and the square root of the mean of the squares of successive RR intervals differences(rMSSD) mean values were significantly lower in patients with AD than in those with MCI or in controls. There were no significant differences between MCI and control groups in mean R-R interval, 5-min total power, VLF, LF and HF or LF/HF ratio. MMSE was negatively correlation with age and duration with illness. HF power emerged as the parameters better related to MMSE. Conclusions: These results suggest that the presence of autonomic cardiac dysfunction in AD patients might be due to a cholinergic deficit in the peripheral autonomic nervous system. The ongoing follow-up of this study population will verify the potential role of the HRV parameters in predicting the degeneration of cognitive functions and mortality rates.