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P1–160: Olfactory identification as a potential marker of presymptomatic Alzheimer's disease
Author(s) -
LafailleMagnan MarieElyse,
Breitner John,
Etienne Pierre,
Poirier Judes,
Fontaine David,
RosaNeto Pedro,
Rajah Natasha
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.383
Subject(s) - repeatable battery for the assessment of neuropsychological status , dementia , olfaction , alzheimer's disease , olfactory system , psychology , disease , neuropsychology , medicine , cognition , audiology , psychiatry , neuroscience
into three groups: dementia, cognitive impairment not dementia (CIND), and those without cognitive impairment (WCI). One year later 199 participants without dementia agreed to be reevaluated according to the same protocol. Results: Multiple regression analysis in the reevaluation sample disclosed no associations between baseline laboratory data and worsening performance in any cognitive tests or functional measurement. In the CIND group, cortisol levels correlated with MMSE (rho1⁄4 -0,33; p1⁄40,015) and Functional Assessment Questionnaire decline (rho1⁄4-0,30 ; p1⁄40,038). sTNFR1 levels correlated with worsening category fluency test performance (rho1⁄40,31 ; p1⁄40,029). Conclusions: Even though the magnitude of the associations was generally weak, in the CIND group we did found significant relationships between cortisol and sTNFR1 levels, and prospective cognitive and functional outcomes, which might encourage further research in the field.