Premium
P1–143: Olfactory stress test (OST) performance in cognitively normal elders is associated with apolipoprotein E (APOE) genotype
Author(s) -
Schofield Peter,
Moore Tammie,
Finnie Sally,
Ebrahimi Houman
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.365
Subject(s) - boston naming test , apolipoprotein e , psychology , audiology , hippocampal formation , neuropsychology , medicine , cognition , neuroscience , disease
computed and used in regression analyses. The Red module, consisting of 529 genes, showed significant correlation with hippocampal volume (right r1⁄40.32, p1⁄40.00007, left r1⁄40.24, p1⁄40.003). The Red module was significantly enriched with transcripts involved in protein phosphorylation and acetylation as well as with brain-expressed genes involved in mitochondrial functions and glutamatergic transmission. Conclusions: We identified a peripheral blood gene co-expression module that is significantly associated with hippocampal volume in NC and MCI and is enriched with brain-expressed transcripts and genes associated with protein post-translational modifications. Further investigations are warranted, into the genes comprising this module and the metabolic pathways they are involved in. Our study suggests that blood based biomarkers could inform the study of cognitive impairment and Alzheimer’s disease.