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P1–121: SREBP‐2‐mediated cholesterol accumulation regulates beta‐amyloid–induced autophagy in APP/PS1/SREBP‐2 mice
Author(s) -
BarberoCamps Elisabeth,
FernandezCheca Jose,
Colell Anna
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.343
Subject(s) - autophagy , cathepsin d , sterol regulatory element binding protein , cholesterol , microbiology and biotechnology , oxysterol , biology , autophagosome , genetically modified mouse , endocrinology , endosome , medicine , transgene , chemistry , sterol , biochemistry , enzyme , intracellular , gene , apoptosis
Comunicación presentada en la Alzheimer's Association 2013 International Conference, celebrada del 13 al 18 de julio de 2013 en Boston (Estados Unidos)Aberrant autophagy in Alzheimer's Disease (AD) is evidenced by a massive build-up of autophagy intermediates, suggesting increased autophagosome formation or defective progression to autophagolysosomes. To date, the exact mechanisms that led to this dysfunction are unknown; however, as similar defects are observed in Niemann-Pick type C1 knockout mice, which accumulate cholesterol in late endosomes/lysosomes, we hypothesize that the impaired cholesterol homeostasis described in AD may play a rolePeer Reviewe