Premium
P1–041: Pharmacological blockade of TGF‐beta signaling in peripheral macrophages mitigates Alzheimer's‐like pathology in preclinical rodent models
Author(s) -
Weitz Tara,
RezaiZadeh Kavon,
Kim Dongin,
Fahmy Tarek,
Town Terrence
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.261
Subject(s) - neuroinflammation , inflammation , microglia , smad , medicine , transforming growth factor beta , innate immune system , immune system , immunology , pathology , transforming growth factor , neuroscience , biology
(EMG) data were recorded from bipolar electrodes in the region of the anterior frontal cortex in thirteen male lemurs. The EEG analysis was focused on the differences between active and passive state (no sleep) during daytime only and on the correlation between cortical EEG markers and EMG activity during nighttime. Results: Fig.1 (top-left) shows the grand-average (N1⁄411) of the normalized EEG power density obtained averaging data recorded during the daytime for the two conditions (active, passive). Fig.1 (top-right) reports the individual values of the normalized EEG power density for the two conditions in eight frequency bands of interest The distributions did not show remarkable outliers. Finally, Fig.1 (middle) shows the mean values (6standard error) of the normalized EEG power density illustrating a statistical ANOVA interaction effect (p<0.00005) between the factors Condition and Band. Duncan planned post-hoc test disclosed that the normalized EEG power density at 1-2 Hz and 2-4 Hz was higher during the active state than during the passive state. Furthermore, it was lower during the active than during the passive condition at 6-8 Hz, 8-10 Hz, and 10-12 Hz (p<0.00005).A statistically significant positive correlation (Fig.1 bottom) was found between the mean rectified EMG activity and the normalized EEG power density at 2-4 Hz. On the contrary, a statistically significant negative correlation (Fig.1 bottom) was found between the mean rectified EMG activity and the normalized EEG power density at 8-10 Hz and 10-12 Hz.Conclusions: In conclusions, this is the first study showing peculiar on-going EEG markers of motor activity in gray mouse lemurs. These results and further studies will improve our understanding of the neurophysiological mechanisms underlying the motor activity and cortical arousal in this animal model and its use in drug discovery for Alzheimer’ disease.