Premium
P1–039: EEG markers of motor activity in mice in physiological and pathological aging
Author(s) -
Del Percio Claudio,
Infarinato Francesco,
Bastlund Jesper Frank,
Clausen Bettina,
Forloni Gianluigi,
Frasca Angelisa,
Bentivoglio Marina,
Fabene Paolo,
Bertini Giuseppe,
Kelley Jonathan,
Dix Sophie,
Richardson Jill,
Drinkenburg Wilhelmus,
Babiloni Claudio
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.259
Subject(s) - electroencephalography , pathological , circadian rhythm , medicine , electrophysiology , psychology , endocrinology , cardiology , physiology , neuroscience
state (gross movements, exploratory movements or locomotor activity) and the passive state (no sleep) were used as an input for EEG power density analysis. Results: Fig. 1(top) shows the grand-average (N1⁄458) of the normalized EEG power density obtained averaging the data of the mice in the frequency range between 0 and 30 Hz for the two conditions (active, passive). The mice were characterized by a higher EEG power density at 1-6 Hz in the passive compared to the active condition. On the contrary, the EEG power density at 6-10 Hz was higher in the active compared to the passive condition. Fig. 1 (middle) reports the individual values of the normalized EEG power density for the two conditions and the following 8 bands of interest: 1-2, 2-4, 4-6, 6-8, 8-10, 10-12, 12-20, 20-30 Hz. The distributions did not show remarkable outliers. Finally, Fig. 1 (bottom) shows the mean values (6standard error) of the normalized EEG power density illustrating a statistical ANOVA interaction (F(7,77)1⁄4 32.2; p<0.0001) between the factors Condition (passive, active) and Band (1-2, 2-4, 4-6, 6-8, 8-10, 10-12, 12-20, 20-30 Hz). Duncan planned post-hoc test disclosed that the normalized EEG power density was higher in the passive compared to the active condition at 1-2, 2-4, and 4-6 Hz (p<0.05). On the contrary, the normalized EEG power density was higher in the active compared to the passive condition at 6-8 and 8-10 Hz (p<0.05). Conclusions: These results suggest that mice without any transgenic mutation are characterized by peculiar EEG marker of motor activity and cortical arousal of interest for the comparison with transgenic mice modeling AD in order to understand the effects of new drugs on brain activity. P1-039 EEGMARKERSOFMOTORACTIVITY INMICE IN PHYSIOLOGICAL AND PATHOLOGICAL AGING