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P1–017: Acetyl‐L‐carnitine rescues scopolamine‐induced memory deficits by restoring insulin‐like growth factor II via decreasing p53 oxidation
Author(s) -
Xiang Wang
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.237
Subject(s) - carnitine , oxidative stress , morris water navigation task , cholinergic , chemistry , malondialdehyde , acetylcarnitine , neuroprotection , pharmacology , acetylcholine , endocrinology , hippocampus , medicine , biochemistry
identified a dose ofMK-801 that reduced accuracy in learning sessions without reducing response rates, and then tested the feasibility of using L655,708, an a 5 GABA A inverse agonist, to rescue MK-801 induced memory deficits.Results:MK-801 decreased accuracy as previous reported. Despite previous reports of LY-655,708 acting as a cognitive enhancer, accuracy was not improved when L-655,708 was administered alone, despite testing at a range of doses, including doses higher than those previously shown to increase cognition in rodents. When given in combination with MK-801, however, there was a complete rescue of MK-801 deficits by LY-655,708.Conclusions: Findings from this study suggest therapeutic targeting of a5GABA A receptors could have clinical efficacy in the treatment of Alzheimer’s disease.