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P1–008: Memantine prevents the reference and working memory impairment caused by sleep deprivation in Octodon degus , a potential animal model for Alzheimer's disease
Author(s) -
Cros Ernesto Tarragon,
Lopez Dolores,
Estrada Cristina,
RosBernal Francisco,
Yuste José Enrique,
Lamberty Yves,
Pifferi Fabien,
Bordet Regis,
Richardson Jill,
Herrero Trinidad
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.228
Subject(s) - memantine , dementia , psychology , cognition , context (archaeology) , donepezil , barnes maze , neuroscience , cognitive decline , sleep deprivation , memory impairment , disease , medicine , biology , paleontology , spatial learning
viewed as the most valid models for understanding cognitive deficits and their neurobiological substrates in the elderly. Grey mouse lemur, Microcebus murinus, shows age-related changes similar to those of aging humans, and some older mouse lemurs show evidence of Alzheimer’s pathology, e.g. amyloid plaques (Languille et al, 2012). The aim of this study is 1) to identify animals with age-related cognitive deficit, 2) to investigate potential detection of blood biomarkers of neurodegenerative progression.Methods: Young (n1⁄413), middle-aged (n1⁄416) and old (n1⁄412) male mouse lemurs were tested in hang and balance tasks, in open field and plus-maze tests, in spontaneous alternation task, novel object recognition test and in the Barnes maze test. APPholoprotein and the 55kDa-APP-CTF bands were determined from platelets by Western blot in 15 males of different ages. Results: Psychomotor capacities and anxiety-related behaviors decreased abruptly from middle to late adulthood. Mnesic functions were unequally affected with aging. Whereas spontaneous alternation task suggested a progressive and widespread age-related decline of spatial working memory, both spatial reference and novel object recognition memory tasks revealed a large individual variability in the middle-aged and old animals. Hierarchical clustering analysis revealed that episodic-like memory was strongly impaired only in 7 middle-aged/old animals. Biomarkers of disease progression were successfully detected in blood. Results show high inter-individual variability especially around middle-age with no clear relation to cognitive status. Conclusions: These behavioral data offer the opportunity to distinguish normal and neuropathological aging in this non-human primate model as compared to human aging. Successful determination of blood biomarkers opens perspective for long term follow up and correlative approach of the neurodegenerative progression in a non human primate species. This research met ethical requirements of the EC Council Directive (2010/63/ UE) and was part of the PharmaCog consortium.