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IC‐P‐195: Region‐specific associations of brain glucose metabolism with age and beta‐amyloid in normal aging
Author(s) -
Oh Hwamee,
Madison Cindee,
Baker Suzanne,
Jagust William
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.194
Subject(s) - precuneus , hypermetabolism , posterior cingulate , carbohydrate metabolism , medicine , pittsburgh compound b , endocrinology , brain aging , alzheimer's disease , anterior cingulate cortex , psychology , neuroscience , disease , cortex (anatomy) , cognition
(ADAS-cog), completed within 14 days of neuroimaging. All images were evaluated applying the same BALI rating schema, to assess lesions in the deepwhitematter, periventricular, basal ganglia and the infratentorial regions, deficits in the cortical gray matter, the extent of dilated small vessels, and global atrophy. Maximum possible BALI1⁄425; higher scores indicate greater damage. Results: The inter-rater agreement rate was consistently high, ranging from 0.96 to 0.98. Under each field-strength and image-type condition, the BALI scores differed significantly between diagnosis (p 0.35, p 0.40, p 0.36, p 3.90, p 3.99, p 0.80). The BALI scores at 1.5T and 3.0Twere significantly correlated, for both T1WI (r1⁄40.94, p 0.95, p<0.001). Conclusions: T1WI and T2WI based BALI scores at 1.5T can be used to capture global brain structural changes and their relations to cognition.