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P4–304: Combination of ZSET1446 (ST101) with galantamine, rivastigmine or memantine synergistically ameliorates cognitive function mediated by increase in the extracellular level of acetylcholine
Author(s) -
Yamaguchi Yoshimasa,
Takeda Kentaro,
Hino Masataka
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1749
Subject(s) - rivastigmine , galantamine , donepezil , memantine , pharmacology , concomitant , acetylcholine , medicine , anesthesia , psychology , dementia , disease
concerning the care receivers’ behavior and abilities to perform their activities of daily living (ADLs). Results: Data were analyzed from 40 caregiver/care receiver dyads with complete sets of data.Significant within-group improvements occurred in the treatment group caregivers in the measures of beliefs about caregiving (P1⁄40.02) and reaction to behavior (P1⁄40.001).When the outcomes were compared (Table 1), the treatment group caregivers had significantly different results (in the expected direction) from those in the control group on measures of stress and beliefs (P1⁄40.04), as well as key outcomes, response to behavior (P1⁄40.03), depression (P1⁄40.03) and burden (P1⁄40.04). Conclusions: A caregiver training intervention focused on the work of caregiving and targeted at improving the knowledge, skills and beliefs benefits caregivers in important outcome dimensions. The results suggest the benefits of providing information, linkage and role coaching to family caregivers of patients with dementia.