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P4–301: A systematic evaluation of the preclinical pharmacokinetic/pharmacodynamic relationship of Alzheimer's disease gold standard drugs in the rat: An in vitro , ex vivo and in vivo comparison
Author(s) -
Jones Caitlin,
Fonteyn Ineke,
Garewal Nikhil,
Wintmolders Cindy,
Cella Massimo,
Wuyts Koen,
Willems Roland,
Duytschaever Hilde,
Calderbanck Emily,
Donck Luc Ver,
Langlois Xavier,
Richardson Jill,
Schenker Esther,
Atack John
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1746
Subject(s) - rivastigmine , galantamine , donepezil , memantine , pharmacology , acetylcholinesterase , ex vivo , pharmacokinetics , medicine , pharmacodynamics , in vivo , nmda receptor , chemistry , dementia , receptor , disease , biology , biochemistry , microbiology and biotechnology , enzyme
P4-301 A SYSTEMATIC EVALUATION OF THE PRECLINICAL PHARMACOKINETIC/ PHARMACODYNAMIC RELATIONSHIP OF ALZHEIMER’S DISEASE GOLD STANDARD DRUGS INTHERAT: AN IN VITRO,EXVIVOAND IN VIVO COMPARISON Caitlin Jones, Ineke Fonteyn, Nikhil Garewal, Cindy Wintmolders, Massimo Cella, Koen Wuyts, Roland Willems, Hilde Duytschaever, Emily Calderbanck, Luc Ver Donck, Xavier Langlois, Jill Richardson, Esther Schenker, John Atack, Janssen R&D, Beerse, Belgium; Janssen Pharmaceutica, Beerse, Belgium; R&D GlaxoSmithKline, Middlesex, United Kingdom; GlaxoSmithKline R&D China Group, Stevenage, United Kingdom; Institut de Recherches Servier, Croissy s/Seine, France; Translational Drug Discovery Group, Brighton, United Kingdom. Contact e-mail: cjones34@its.jnj.com