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P4–208: Predicting cognitive function from clinical measures of mobility and health status: A L1‐L2 regularized regression approach
Author(s) -
Bolandzadeh Niousha,
Kording Konrad,
Salowitz Nicole,
Hsu C. Liang,
Davis Jennifer C.,
Sharma Devika,
LiuAmbrose Teresa
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1600
Subject(s) - montreal cognitive assessment , cognition , medicine , gerontology , balance (ability) , population , physical therapy , quality of life (healthcare) , cognitive impairment , nursing , environmental health , psychiatry
Figure 1 A (r 1⁄4 -0.649, P < 0.001). Increase in CVR with age is shown in Figure 1 B (r1⁄4 0.259, P< 0.05). Reduction in nTBVwith agewas correlated negatively with increases in CVR (r1⁄4 -0.344, P < 0.01) (Figure 1 C). However, no age-related differences in nTCBF were observed (r 1⁄4 0.03, P 1⁄40.815) (Figure 1 D). Conclusions: Increases in cerebrovascular resistance with age suggest the presence of cerebral vasoconstriction and/or vascular rarefaction which may be related to the reduction in brain tissue volume. However, no age-related differences in normalized brain perfusion indicate that neurovascular coupling is likely to be maintained intact during normal aging.