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P4–163: Symptoms of androgen deficiency in Chinese older men with mild cognitive impairment
Author(s) -
Chu Leungwing
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1554
Subject(s) - androgen deficiency , medicine , cognitive impairment , androgen , testosterone (patch) , morning , free testosterone , endocrinology , sex hormone binding globulin , disease , hormone
Geriatric Depression Scale (GDS). Cognitive function tests including mini mental status examination (MMSE), letter fluency, Boston naming test, verbal learning tests, and trail making test-A (TMT-A)were conducted. Blessed Dementia Scale-Activities of Daily Living (BDS-ADL) was utilized to assess daily functioning. In both groups, correlation between GDS with cognitive function measures and BDS-ADL were analyzed. Results: In aMCI group, correlation analysis showed a significant positive correlation between GDS and BDS-ADL (r1⁄40.321, p<0.001), but no significant correlations were observed between GDS and cognitive function measures. In contrast, correlation analysis in mild AD group showed no significant correlation between GDS and BDS-ADL, but a significant positive correlation was found between GDS with TMT-A time (r1⁄40.315, p<0.05). Conclusions: The present study suggests that depression severity has negative impact on daily functioning rather than cognitive functioning in patients with MCI. However, in patients with AD cognitive functioning rather than daily functioning is affected by depression severity.