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IC‐P‐156: Association between higher fasting serum glucose levels and the pattern of lower regional gray matter volumes in cognitively normal adults
Author(s) -
Bartell Jared,
Burns Christine,
Thiyyagura Pradeep,
Li Alex,
Parks Stephanie,
Protas Hillary,
Lee Wendy,
Fleisher Adam,
Kaszniak Alfred,
Chen Kewei,
Reiman Eric
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.153
Subject(s) - precuneus , statistical parametric mapping , posterior cingulate , orbitofrontal cortex , atrophy , magnetic resonance imaging , medicine , neuroimaging , apolipoprotein e , cardiology , psychology , prefrontal cortex , endocrinology , functional magnetic resonance imaging , neuroscience , disease , radiology , cognition
two subject groups. Results: Ab positive groups had significantly higher HCIs than the Ab negative groups (p1⁄40.0024). HCIs were significantly associated with poorerMMSE and ADAS-Cog scores in the Ab positive group (r1⁄4-0.38, p1⁄40.001 and r1⁄40.36, p1⁄40.002, respectively) but not in the Ab negative group (r1⁄40.007, p1⁄40.936 and r1⁄40.06, p1⁄40.458, respectively). Conclusions: Fibrillar A b burden in cognitively normal older adults is associated with an AD-related index of cerebral hypometabolism, and this index is associated with poorer clinical ratings in those who are Ab positive.