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P4–134: Monetary decision‐making in behavioral variant frontotemporal dementia and Alzheimer's disease
Author(s) -
Wood Kristie,
Chiong Winston,
Sturm Virginia,
Perry David,
Kramer Joel H.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1524
Subject(s) - frontotemporal dementia , psychology , punishment (psychology) , executive dysfunction , disease , executive functions , iowa gambling task , anticipation (artificial intelligence) , dementia , audiology , cognition , clinical psychology , developmental psychology , medicine , psychiatry , neuropsychology , artificial intelligence , computer science
Background: The ADAS-Cog and ADCS-ADL, developed in the United States are key endpoints in global AD clinical drug trials. Careful cross cultural adaptation of the scales is critical to ensure equivalent measurement of cognitive and functional treatment effects. Anecdotal reports from AD experts in some Asian countries indicated that existing translations of the scales could be improved by more careful adaptation to the local culture. To address the issue of potential cultural bias, a rigorous translation and cultural adaptation process that included local expert input was undertaken for the ADAS-Cog and ADCS-ADL in Japan, South Korea, and China. Methods: An expanded linguistic validation of the ADAS-Cog and ADCS-ADL was designed to capture and address specific issues with original scale items that were potentially problematic in Eastern cultures. MAPI Institute’s linguistic validation methodology, which includes forward and backward translations and cognitive interviews of the translated scales, was expanded to include input from local AD experts experienced in scale administration. MAPI Institute conducted meetings with the experts to identify and address specific translation and cultural issues at each step of the translation process. Results: A number of items in the ADAS-Cog and ADCS-ADL were identified by the experts as needing cultural adaptation. Modifications resulted in adjustments to some individual scale items, instructions or expanding the range of correct, acceptable responses. Types of modifications include. Scale Item Modification Naming Objects and Fingers, Word Recall and Recognition Modified to include culturally relevant objects Naming Objects and Fingers, Orientation and Ideational Praxis Modified and expanded the range of culturally acceptable responses ADCSADL Modified to include culturally relevant ADLs on several items. Conclusions: This project highlights the value of incorporating local experts with experience specific to administration of the scales. Experts are uniquely qualified to identify culturally biased or inappropriate language that if left unchanged, may result in items that are not conceptually equivalent to the original scale, thus affecting results.