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P4–115: White matter hyperintensities and activities of daily living in people with dementia
Author(s) -
Shin HaeEun,
Lee Sibaek,
Park JeongWook
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1505
Subject(s) - activities of daily living , dementia , hyperintensity , barthel index , psychology , neuropsychology , medicine , physical therapy , disease , psychiatry , magnetic resonance imaging , cognition , radiology
on interview with caregiver, direct interaction with the patient, and additional information from patient record, minimizing potential inaccuracies or misinterpretation of symptoms by the caregiver.We investigated 312 participants from five Brazilian centers (156 patient/knowledgeable informant dyads), who completed the NPI-C with two blinded raters, totaling 624 observations. The raters determined dementia severity by Mini-Mental State Examination, Clinical Dementia Rating, Pfeffer Activities Questionnaire, and Global Deterioration Scale. Two independent raters interviewed each knowledgeable informant/patient dyad at different times, and determined the final score in each NPI-C domain. Inter-rater reliabilities per each domain were calculated using intraclass correlations. Convergent validity was estimated by Pearson correlations between NPI-C domains and selected scales. Results: The mean age of patients was 76.7y; mean education was 5.5y. According to CDR, 60 patients were classified as mild, 53 as moderate, and 43 as severe. Inter-rater reliability was strong for all domains of the NPIC x NPI traditional (r1⁄40.923). Caregiver reliability, available for 109 individuals, was moderate (r1⁄40.601). The convergent validity was supported by strong coefficient correlations of NPI-C domains: NPI-C/Apathy-Indifference x Apathy Inventory (0.942); NPI-C/Agitation x Cohen-Mansfield Agitation Index (0.772); NPI-C/Aggression x Cohen-Mansfield Agitation Index (0.769); NPI-C/Depression-Dysphoria x Cornell Scale for Depression in Dementia (0.736); NPI-C/Delusions x Brief Psychiatric Rating Scale (0.713); NPI-C/Aberrant Vocalizations x Cohen-Mansfield Agitation Index (0.684); NPI-C/Hallucinations x Brief Psychiatric Rating Scale (0.432). Conclusions: The NPI-C is a comprehensive scale, which provides accurate measurement of neuropsychiatric symptoms in dementia with high convergent validity and inter-rater reliability for Brazilian community. The availability of this Brazilian version might represent a contribution for research and clinical trials on neuropsychiatric syndromes in dementia.