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P4–108: Evidence of microvascular network alterations in the retinas of people with Alzheimer's disease
Author(s) -
Cheung Carol,
Ong YiTing,
Ikram Mohammad Kamran,
Hilal Saima,
Catindig JosereeAnn S.,
Venketasubramanian Narayanaswamy,
Yap Philip,
Seow Dennis,
Chen Christopher,
Wong Tien Yin
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1498
Subject(s) - medicine , microcirculation , cardiology , retinal , odds ratio , tortuosity , retina , pathology , ophthalmology , neuroscience , psychology , geotechnical engineering , porosity , engineering
Background: Performance-based instrumental activities of daily living (IADL) measurement is thought to improve validity and reliability of conventional tools relying on proxy-report. Aims of this study were to develop and validate a performance-based measurement of IADL in the use for elderly patients with cognitive impairment in Taiwan and other Chinesespeaking communities. Methods: Referring to current versions of performance-based IADL, we develop a new Taiwan Performance-based IADL (TPIADL) with some changes in test items to minimize literacy dependency and render them compatiblewith local culture. Participants performed tasks, including finding a telephone number, making change, reading the ingredients on a can of food, finding food items on a shelf, and reading instructions on a medicine container. Total score of TPIADL ranged from 0 to 15, with higher score indicating more disable. Altogether, 121 elders were invited to participant in this study, with 43 patients Alzheimer’s disease, 29 with amnestic mild cognitive impairment (aMCI) and 49 without cognitive impairment. Mean differences of total score of TPIADL were compared. The criteria validity of the TPIADL for dementia due to ADwas examined using Relative operating curve (ROC) analyses. Pearson’s correlation was calculated to represent convergent validity. Results: The TPIADL scores were significantly correlated with LawtonIADL (r1⁄40.76, p<0.001). The area under the ROC curve was 0.90 (95% C.I.1⁄40.84, 0.97). The validity indices of the PIADL were represented with sensitivity, specificity, (PPV), (NPV) and (OMR). The optimal cut-off point for the TPIADL should be 6/7, which gives a sensitivity of 84.6%, a specificity of 75.6%. Conclusions: We suggested TPIADL is culture-sensitive and validated instrument to measure IADL for the elders speaking Chinese.