Premium
P4–099: Donepezil can prolong lifespan in Alzheimer's disease: The Tajiri Project 1999–2012
Author(s) -
Meguro Kenichi,
Kasai Mari,
Nakai Megumi,
Kato Yuriko,
Akanuma Kyoko,
Meguro Mitsue,
Nakamura Kei,
Nakatsuka Masahiro,
Ishii Hiroshi,
Yamaguchi Satoshi
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1488
Subject(s) - donepezil , medicine , dementia , disease , medical record , rivastigmine , concomitant , institutionalisation , cholinesterase , alzheimer's disease , gerontology , pediatrics , psychiatry
Background: The differential diagnosis of mood disorder with associated dementia-like symptoms (pseudodementia) or Alzheimer disease (AD) may be difficult. Although the Mini Mental State Examination (MMSE) and magnetic resonance imaging (MRI) are used as diagnosis for dementia, they cannot adequately identify pseudodementia or AD. We studied that the effectiveness of VSRAD (Voxel-Based Specific Regional Analysis System for Alzheimer’s Disease) in differentiating between mood disorder and AD. Methods: The subjects consisted of 75 patients with pseudodementia or AD (mean age 73.467.01 years, average Z score 1.81 61.18, average MMSE score 22.73 65.43). They were divided into three groups, that is, the mood disorder group (n1⁄433), the AD group (n1⁄430) and the mood disorder group of later development of AD (n1⁄412). We compared the MMSE and degree of parahippocampal gyrus atrophy as a Z score of the VSRAD to MRI data between the three types of dementia. Moreover, Receiver operating characteristic (ROC) curve analysis was used to calculate the cut-off value of a Z score in differentiating between mood disorder and AD.Results: There are correlations between theMMSE and a Z scores, the Z scorewas highly in the group that had a lowerMMSE score. The mood disorder group had significantly lower Z scores than the AD group (p < 0.001). The mood disorder group had significantly lower Z scores than the mood disorder group of later development of AD (p <0.001). The cut-off value of a Z score between the mood disorder group and the AD group was 1.52(sensitivity of 91.67% and specificity of 84.85%), there is a high possibility of AD when a Z score is higher than 1.52. The cut-off value of a Z score between the mood disorder group and the mood disorder group of later development of AD was 1.32, there is a high possibility of mood disorder of later development AD when a Z score is higher than 1.32. Conclusions: It is suggested that VSRAD is an effective auxiliary diagnosis for differentiating between mood disorder with associated dementia-like symptoms and Alzheimer disease, and make it possible to learn the risk of Alzheimer’s disease onset in mood disorder.