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P4–079: Functionality and cognitive performance of patients with behavioral variant frontotemporal dementia
Author(s) -
Bento da Silva Thais,
Bahia Valéria,
Carvalho Viviane Amaral,
Guimarães Henrique,
Caramelli Paulo,
Balthazar Marcio,
Damasceno Benito,
Bottino Cassio,
Brucki Sonia,
Nitrini Ricardo,
Yassuda Mônica
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1468
Subject(s) - frontotemporal dementia , dementia , clinical dementia rating , geriatric depression scale , depression (economics) , clinical psychology , cognition , disease , rating scale , anxiety , psychiatry , medicine , psychology , depressive symptoms , developmental psychology , economics , macroeconomics
temporo-parietal areas. MIBG myocardial scintigraphy showed mild abnormalities. Patient 3: A 75-year old right-handed man became confused with multiple tasks for six months and then had difficulty in word finding and comprehension. Impairment in naming, comprehension and repetition of sentences, phonological paraphasia and cognitive decline was detected. Brain atrophy and hypoperfusion were noted at the left temporo-parietal areas. Uptake on MIBG myocardial scintigraphy was slightly decreased. P-tau and A b 42 in CSF suggested AD pathology. Patient 4: A 67-year old right-handed woman became forgetful and poorer in consecutive calculation, and the family noticed that the patient often misidentified her two sons interchangeably. At presentation, she scored 24/30 on a short cognitive test; mental manipulation of numbers was more impaired than memory. Although the patient did not show physical signs, abnormal MIBGmyocardial scintigraphy and normal brain MRI suggested DLB. SPECT showed bilateral frontoparietal uptake decreases. Two years after the onset, the patient developed difficulty in producing the first sound of sentences. Language evaluations revealed characteristics of apraxia of speech but no aphasia. Conclusions: Clinical DLB may present logopenic aphasia and rarely apraxia of speech. Concomitant AD pathology may possibly contribute to logopenic aphasia in DLB.