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P4–063: Poor prognostic factors in subcortical vascular dementia: A longitudinal cohort study of amyloid PET Imaging for subcortical vascular dementia
Author(s) -
Ye Byoung Seok,
Kim Geon Ha,
Cho Hanna,
Noh Young,
Kim HeeJin,
Yoon Cindy,
Kim Sook Hui,
Park Hee Kyung,
Kim Sung Tae,
Choe Yearn Seong,
Lee KyungHan,
Kim Jae Seung,
Oh Seung Jun,
Seo Sang Won,
Lee JaeHong,
Na Duk L.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1452
Subject(s) - dementia , cohort , cognitive decline , neuropsychology , medicine , boston naming test , pittsburgh compound b , stroop effect , psychology , proportional hazards model , cognitive reserve , cardiology , cognition , disease , psychiatry
containing tests for attention, language, memory, visuospatial function and frontal/executive function. Using Korean form of Geriatric Depression Scale (KGDS), 366 subjects were divided into non-depressed group (n1⁄4187, KGDS 6) and depressed group (n1⁄4179, KGDS 22). Results: The depressed MCI group had lower Korean Mini-mental State Examination (K-MMSE) scores (p<0.001), and poor Instrumental Activities of Daily Living (I-ADL) scores (p<0.008). The test scores of the two groups were similar on memory (p1⁄40.403) and language domain (p1⁄40.098). The test scores on attention (p<0.001), visuospatial function (p<0.001), executive function (p<0.001) domains were significantly lower in depressive group. Conclusions: In studies on late life depression subjects, it is well known that depressive patients show more impairment in information processing speed, visuospatial and executive abilities. Our results on the MCI with depression group are in agreement with earlier studies. Among the five cognitive domains, the impairments of attention, visuospatial and executive functions were more severe in depressed subjects than in non-depressed subjects. Factors associated with the presence of depression in MCI subject were; being women (p<0.001), and of lower education (p <0.001). Illness duration of MCI was not associated with the presence of depression (p1⁄40.136). Longitudinal follow up of these subjects may be needed to verify the prognostic significance of depression in MCI subjects, whether being depressed raises the likelihood of conversion of MCI to AD.