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P3–312: Do “healthy” women live too long?
Author(s) -
Kuller Lewis,
Lopez Oscar,
Mackey Rachel,
Rosano Caterina,
Becker James,
Newman Anne
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1387
Subject(s) - medicine , dementia , subclinical infection , incidence (geometry) , disease , cardiology , clinical dementia rating , pediatrics , physics , optics
1⁄40.002; k1⁄4197; x,y,z1⁄4[24,-64,30]; TC: p FWE-corr 1⁄40.005; k1⁄4159; x,y,z1⁄4[18,-52, 10]) such that statin-treated individuals with higher LDL-C and TC had greater increases in rCBF than statin-treated persons with lower lipid levels (Figure). Conclusions: In preclinical middle-aged adults at risk for AD, higher baseline lipid levels predicted greater simvastatin-induced increases in rCBF in the right precuneus, an area of the brain associated withmemory retrieval. As personswith AD have reduced rCBF in keymemory areas of the brain, such findings may suggest beneficial effects of statins in reducing AD risk particularly in individuals with more atherogenic lipid levels. Further investigation is needed to clarify the clinical implications of these statin-induced effects on rCBF and other preclinical processes related to AD.