Premium
P3–294: Detection of distinct neuropsychiatric symptom clusters at early‐ versus late‐stages of Alzheimer's disease
Author(s) -
Rockwood Kenneth,
Mitnitski Arnold,
Richard Matthew,
Kurth Matthias,
Kesslak Patrick,
Abushakra Susan
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1368
Subject(s) - mood , irritability , worry , anxiety , psychiatry , dementia , psychology , disease , clinical psychology , medicine
Alzheimer's disease (AD) in general is characterized by common cognitive and behavioral dysfunction that evolve as the disease progresses. The complexity of AD is reflected in patient heterogeneity and emergence of different symptoms as the disease progresses. We employed a network visualization approach to display significant symptom associations of 60 symptoms by the severity of dementia. Background • NPS clustering patterns were similar between the MCI/Mild and Moderate/Severe severity groups, with a distinct depressive cluster and a distinct psychotic cluster.