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IC‐P‐134: Cerebral microbleeds and the risk of mortality in the general population
Author(s) -
Akoudad Saloua,
Ikram Mohammad,
Koudstaal Peter,
Hofman Albert,
Lugt Aad,
Vernooij Meike
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.131
Subject(s) - medicine , hazard ratio , proportional hazards model , population , cardiology , dementia , cerebral amyloid angiopathy , disease , confidence interval , environmental health
(N1⁄426). Increased statistical power of QT analyses was demonstrated by some of these analyses, e.g., the FRMD6 gene was identified in three imaging genetics studies [1-3] and later validated by a case control GWAS with a much larger sample [4]. Conclusions: The availability of ADNI genetic and multimodal phenotypic data has yielded numerous research findings that demonstrate the power of multidimensional quantitative phenotypic data for identifying novel genetic variants. Ongoing analyses are beginning to place known and novel genetic findings from ADNI into a systems biology framework, to better understand the pathways involved in the disease trajectory.[1] Furney et al., Mol Psychiatry, 2011, 16(11):1130-8. [2] Potkin et al., PLoS One, 2009, 4(8):e6501. [3] Stein et al., NeuroImage, 2010, 53(3):1160-74. [4] Hong et al. Hum Mutat, 2012, 33(3):521-9.