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P3–217: Effect of intellectual lifestyle and Alzheimer's disease biomarkers on rate of cognitive decline: Mayo Clinic Study of Aging
Author(s) -
Vemuri Prashanthi,
Lesnick Timothy,
Przybelski Scott,
Knopman David,
Machulda Mary,
Lowe Val,
Mielke Michelle,
Roberts Rosebud,
Geda Yonas,
Gregg Brian,
Senjem Mathew,
Gunter Jeffrey,
Petersen Ronald,
Jack Clifford
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1290
Subject(s) - cognitive decline , cognition , baseline (sea) , gerontology , medicine , effects of sleep deprivation on cognitive performance , dementia , population , pittsburgh compound b , psychology , disease , psychiatry , oceanography , environmental health , geology
dementia when compared to the individuals with no formal education (N1⁄490). After adjustment for sociodemographics and neuropathologic features including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small vessel disease, and Lewy bodies, 1-4 years of education education had an OR1⁄40.54, 95%CI 0.28-1.02; p1⁄40.06;>4 years had an OR1⁄40.38, 95%CI 0.17-0.88; p1⁄40.02. Higher brain weight was also associated to lower frequency of dementia in adjusted analysis (OR1⁄4 0.64, 95% CI: 0.49-0.85, p1⁄40.002). The interaction between education and brain weight was not related do dementia (p1⁄40.37). Conclusions: Higher education and brain weight are associated with lower frequency of dementia. Education and brain weight may represent different domains of neural reserve.