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P3–200: Limited literacy predicts dementia incidence among older adults
Author(s) -
Kaup Allison,
Simonsick Eleanor,
Harris Tamara,
Satterfield Suzanne,
Metti Andrea,
Ayonayon Hilsa,
Rubin Susan,
Yaffe Kristine
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1272
Subject(s) - dementia , medicine , hazard ratio , incidence (geometry) , literacy , gerontology , cohort , health literacy , proportional hazards model , demography , educational attainment , cohort study , psychology , confidence interval , pedagogy , health care , physics , optics , economics , economic growth , disease , sociology
enhanced cognition remains poorly defined, there is now an urgent need to further delineate the role of BP in AD. We examined the relationship of BP to hippocampal volume in the ADNI data, yet the most robust longitudinal data to date. Methods: An exhaustive list of publications detailing the ADNI methods is currently available elsewhere. The DANI data used in this analysis were downloaded on October 10, 2012. Initially we used Univariate analysis to examine the data. Where appropriate, Proc GLM (General Linear Model), and Multiple Logistic Regression analyses were used to discern the relationships of BP to hippocampal volume, and the LSMeans in GLM to estimate mean values. All analyses were performed in the Statistical Analysis System (SAS), Research Triangle North Carolina. Results: Of the 1210 subjects initially examined for these analyses, 558 and 240 subjects had complete data on important covariates at 2 and 4 years follow-up, respectively. In our final model that adjusted for age, gender education and ethnicity, increased double product (SBP * heart rate) a measure the heart’s work load and SBP, related to reduced hippocampal volume at 24 months and 48 months, respectively (all P < 0.05). Conclusions: We concluded that SBP and double product were associated with reduced hippocampal volume in the ADNI study. Even if better control of BP translates into very small improvements in cognition, substantial gains might be realized given the total number of persons with hypertension in the United States.