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P3–177: Effect of hyperinsulinemia on cortical thinning
Author(s) -
Yoon Cindy,
Seo Sang Won,
Kim Geon Ha,
Noh Young,
Cho Hanna,
Ye Byoung Seok,
Kim HeeJin,
Na Duk L.
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1249
Subject(s) - hyperinsulinemia , insulin resistance , medicine , quartile , insulin , endocrinology , diabetes mellitus , cognitive decline , surrogate endpoint , biomarker , disease , biology , dementia , confidence interval , biochemistry
with a proportion of 7.97% (p-value <0.0001) within our study population. Simulation study also shows that failure to account for this immune subgroup may result in bias in survival estimates and errors in identifying risk factors. Conclusions: Our study suggests that some subjects are immune to dementia. This subgroup of immune individuals should be adjusted for in any survival analysis to produce correct estimates for the probability of the age of onset of dementia and to identify correct risk factors for the age of onset of dementia.