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P3–161: Antithrombotic medication use and dementia incidence among people with mild cognitive impairment and atrial fibrillation
Author(s) -
Meranus Dana,
Kukull Walter
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1233
Subject(s) - medicine , dementia , antithrombotic , atrial fibrillation , incidence (geometry) , stroke (engine) , cohort , risk factor , physical therapy , disease , mechanical engineering , physics , optics , engineering
aMCI was examined using Cox proportional hazards’ models, adjusting for gender, race, education, and age at baseline. PSS was examined using the continuous PSS score, as well as a dichotomized categorical score (highest decile vs. others). Results: 535 individuals were eligible for inclusion and had a median follow-up of 3.4 years. The cohort had a mean age of 80 years (s.d.1⁄4 5.5) at baseline and was predominantly female (64%) with a mean of 14.2 years of education. 75 participants (14.0%) developed incident aMCI. In the fully adjusted model, a 5 pointincrease in PSS score was associated with an increased risk of incident aMCI (HR1⁄4 1.18; 95% CI:1.01-1.36, P1⁄40.034). Participants with PSS above the 10th percentile were at higher risk of incident aMCI compared to the rest of the sample in the fully adjusted model (HR1⁄41.99, CI: 1.17-3.38, P1⁄40.011). Conclusions: High levels of perceived stress, as measured by the PSS, were associated with an increased risk of incident aMCI. This result may have implications for potential treatment or intervention for early cognitive impairment due to memory. Though a causal relationship is plausible, we cannot exclude reverse causality.