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P3–149: Circadian activity rhythm patterns in nondemented older women and cognitive function 5 years later
Author(s) -
Walsh Christine,
Tranah Greg,
Stone Katie,
Blackwell Terri,
Redline Susan,
Paudel Misti,
AncoliIsrael Sonia,
Kramer Joel H.,
Yaffe Kristine
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1220
Subject(s) - verbal fluency test , audiology , actigraphy , dementia , cognition , effects of sleep deprivation on cognitive performance , psychology , cognitive decline , circadian rhythm , medicine , psychiatry , neuropsychology , disease
symptoms burden, women in the highest quartile of cumulative depressive symptom burden had 19% more MMSE errors over time (95% CI1⁄414%,23%) and 19% worse Trails B score (95%CI1⁄416%,22%). Similarly, those with the highest quartile of cumulative depressive symptom burden had worse scores on most of the Year 20 cognitive tests and a two-fold greater likelihood of developing dementia or MCI (OR1⁄42.0; 95% CI1⁄41.38,2.90). Conclusions: Long-term cumulative depressive symptom burden was independently associated with cognitive decline, worse cognitive scores and greater odds of developing dementia orMCI. Cumulative depressive symptom adversities may increase the risk of cognitive decline and late-life dementia/MCI. Older adults with a history of depression should be closely monitored for recurrent episodes or unresolved depressive symptoms as well as any cognitive deficits.