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IC‐P‐125: Posterior cingulate network adaptation in Alzheimer's disease
Author(s) -
Parent Maxime,
Wang Seqian,
Mohades Sara,
Beaudry Thomas,
Rowley Jared,
Cheewakriengkrai Laksanun,
Shin Monica,
Leuzy Antoine,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.122
Subject(s) - resting state fmri , posterior cingulate , neuroimaging , neuroscience , white matter , voxel , alzheimer's disease , psychology , alzheimer's disease neuroimaging initiative , spatial normalization , medicine , magnetic resonance imaging , functional magnetic resonance imaging , disease , cognition , cognitive impairment , radiology
onto the baseline image and a level set algorithm was applied to refine the shape and smooth the boundary. The MTL of the baseline image was then mapped onto the subject’s follow-up image to measure volume change. Algorithm Validation: Baseline and 24 month follow-up 1.5 Tesla 3D T 1 -weighted anatomical images from theA lzheimer disease neuroimaging initiative (ADNI) were randomly selected for 50 normal subjects, 50 people with mild cognitive impairment (MCI) and 50 people with AD. Change in MTL volume was compared to change in hippocampal volume measured by Freesurfer. Results: The average (mm 3) DMTL (6SEM) was 68.1(635.1) in normal, 187.1(637.7) in MCI, and 300.3(633.8) in AD groups. There was a significant difference between all groups (one way ANOVA, p<0.0001). A repeatedmeasures t -test showed that therewas a significant different betweenNEC/MCI (p<0.05),NEC/AD(p<0.0001) andMCI/ AD (p<0.05). Results for Freesurfer were similar but did not detect significant differences between the MCI and AD groups. Conclusions: A significant difference in MTL atrophy was detected with the new segmentation approach between normal elderly, people with MCI and people with AD. This fully automated segmentation algorithmmay increase themeasurement accuracy associated with structural change and can be extended to measure any brain region.