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P3–143: Environmental enrichment exerts a stronger impact on cognitive performance than does social interaction or nutritional supplementation
Author(s) -
Shea Thomas,
Doulames Vanessa,
Lee Sangmook
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1214
Subject(s) - environmental enrichment , cognition , effects of sleep deprivation on cognitive performance , oxidative stress , cognitive decline , psychology , dementia , physiology , gerontology , medicine , neuroscience , disease
significantly higher (b1⁄4 0.331, p1⁄40.03) but not in the top intake tertile (b1⁄4 0.116, p1⁄40.49). Compared with VAMP levels for individuals in the lowest tertile of total n-3 fatty acid intake, levels were higher only among individuals in the third but not the second tertiles of intake (for tertile 2, b1⁄4 0.228, p1⁄434; for tertile 3, b1⁄40.50, p1⁄4.04). Conclusions: This study suggests that one potential biological mechanism underlying the relation of long-chain n-3 fatty acids to brain health during aging is maintenance of neural reserve by sustaining higher levels of presynaptic proteins, vital to neural signaling.