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P3–138: Compromised nutrient uptake and metabolism in Alzheimer's disease: Possible implications for nutritional management of Alzheimer's disease
Author(s) -
Sijben John,
Wilde Martijn,
Wijk Nick,
Groenendijk Martine,
Kamphuis Patrick
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1209
Subject(s) - nutrient , vitamin c , biology , endocrinology , disease , medicine , physiology , chemistry , biochemistry , ecology
(b1⁄40.319, p1⁄40.005) and lower TMT-A (b1⁄4 -0.652, p1⁄4 0.020), both indicating better performance. Higher E% from fat (b1⁄40.08, p1⁄40.017) and lower E % from carbohydrates (b1⁄4-0.08, p1⁄40.017) were associated with better performance measured by total score but not TMT-A. Among foods and micronutrient intake, the most significant in relation to cognitive performance were consumption of vegetables (but not fruit), and intake of vitamin E. Those with higher vegetable consumption had better performance in total score (p for trend across tertiles of intake 0.004) and TMT-A (p-trend 0.000). Similarly, increasing vitamin E intake was associated with better performance in both the total score (p-trend 0.001), and TMT-A (p-trend 0.007). Furthermore, higher consumption of fish (p-trend 0.003), and higher intake of folate (p-trend 0.028), respectively, were associated with better TMT-A. Conclusions: Higher intakes of energy and vitamin E, and higher vegetables consumption were associated with better cognitive performance among older adults at risk for dementia. Whether cognitive dysfunction dilutes diet or diet enhances cognitive function remains unclear in a cross-sectional setting. The FINGER intervention may clarify the direction of these associations.