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P3–131: Influence of amyloid deposition on cerebral glucose metabolism in mild cognitive impairment subjects
Author(s) -
Fan Zhen,
Edison Paul
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1202
Subject(s) - medicine , carbohydrate metabolism , endocrinology , amyloid (mycology) , standardized uptake value , alzheimer's disease , positron emission tomography , biomarker , psychology , pathology , chemistry , nuclear medicine , disease , biochemistry
the pathological decline in selective attention in AD. Methods: This pilot study included healthy elderly and mild AD patients. Diffusion tensor imaging (DTI) data was collected in 30 directions using a Siemens 3T scanner. A 3DMPRAGE anatomical scan was co-registered to the diffusion data for 3D analysis.Diffusion-weighted imaging data was transformed into common Talaraich space and spherical predetermined regions of interest (ROI’s) were placed individually at the right and left PCC (radius 4.5mm), precuneus (radius 7.5mm) and IFG (radius 8mm) for both groups.Mean FAvalues for each ROI were computed. A MANOVAwas applied to test the effect of group on mean FAvalues for all ROI’s. Results: There was a significant effect of group (AD vs. HC) on mean FA values in the ROI’s, Wilks L 1⁄4 0.1, F(6,7)1⁄4 10.03, p< .05. Separate univariate ANOVA’s revealed a significant difference between HC and AD for the right precuneus F(1,12) 1⁄4 5.07, p< .05 and the right inferior frontal gyrus F(1, 12)1⁄4 6.45, p< .05. Conclusions:Our pilot study confirms that FA is altered in AD compared to healthy aging in frontal and DMN regions. Our next step will be to correlate cognitive and behavioural scores with FA to further understand the relationship between white matter pathology and cognitive deficits in AD.