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P3–087: Type 2 diabetes is associated with accelerated longitudinal white matter degeneration in the elderly
Author(s) -
Maillard Pauline,
Carmichael Owen,
Mungas Dan,
Reed Bruce,
DeCarli Charles
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1157
Subject(s) - dementia , medicine , white matter , diabetes mellitus , cardiology , hyperintensity , voxel , diffusion mri , brain size , cognitive decline , disease , magnetic resonance imaging , endocrinology , radiology
of other regions were particularly located in the temporo-parietal and PCC/ precuneus regions (out-going); while amyloid hubs that are being influenced by a high amount of regions across the brain were located in the lateral and medial frontal regions (in-coming) (see an example of an individual subject in Fig. 1-B and 1-C). Conclusions: Although these findings are promising to understand the dynamical binding of PIB and network activity of the amyloid pathology in preclinical stages of AD, further work is needed in order to clarify the specific meaning of the temporo-spatial relationships between amyloid hubs.