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P3–069: Losartan‐induced hypotension impairs learning and memory
Author(s) -
Xinghua Liu,
Xiji Shu
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1139
Subject(s) - losartan , morris water navigation task , malondialdehyde , medicine , endocrinology , oxidative stress , neurodegeneration , blood pressure , angiotensin ii , hippocampus , disease
of leptin and the leptin receptor in AD and control patients. We analyzed the concentration of leptin in cerebrospinal fluid (CSF) as well as the concentration and localization of leptin, and the full-length leptin receptor, in the hippocampi of AD and control patients. Results: Significant elevations in the level of leptin in both CSF and hippocampal tissue of AD patients, when compared to age-matched control cases, indicate a physiological upregulation of leptin in the disease. However, leptin receptor mRNA levels were decreased in AD brain tissue, and the leptin receptor protein was strikingly co-aggregated with neurofibrillary tangles, suggesting a severe discontinuity in the leptin signaling pathway in AD.Conclusions:Our results strongly suggest that leptin resistance in the hippocampusmay play a role in the characteristic changes associated with the disease. These findings are the first to demonstrate such dysregulated leptin-signaling circuitry and provide novel insights into the possible role of aberrant leptin signaling in AD. The pathological implication of neuronal leptin resistance and its molecular mechanism will be discussed further in the presentation.