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P3–035: Investigating nuclear hormone receptors as a target for Alzheimer's disease
Author(s) -
Iyer Sangeetha,
Kushwaha Anushri,
Crisp Ashley,
PierceShimomura Jon
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1104
Subject(s) - neurodegeneration , receptor , nuclear receptor , microbiology and biotechnology , retinoid x receptor , biology , liver x receptor , amyloid precursor protein , cholinergic , neuroscience , chemistry , medicine , alzheimer's disease , disease , transcription factor , biochemistry , gene
in the hippocampus will result in cognitive impairment. Degeneration of synapses also speed up neurodegenerative processes in AD. On the other hand, Ab peptide and tau protein in the pathogenesis of AD can further enforce neurodegeneration. This can form a vicious cycle to promote deterioration of the brain and cognitive functions. Our study may explain why depression can be a risk factor for promoting cognitive impairment in AD.