Premium
P3–034: Investigating biological mechanisms of corticosterone‐induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease
Author(s) -
ChuenChung Chang Raymond,
Wuwongse Suthicha,
Wong Ginger,
WingTing Tsang Andrea,
Zhang Endong,
ShukYee Cheng Sally,
HiuLing Hung Clara,
WaiMan Lau Benson,
Ho Yuenshan,
So KwokFai,
Law Andrew
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.1103
Subject(s) - corticosterone , neurodegeneration , synaptophysin , hippocampal formation , neuroscience , hyperphosphorylation , hippocampus , biology , medicine , endocrinology , microbiology and biotechnology , immunohistochemistry , disease , hormone , kinase
This journal suppl. contain abstracts of AAIC2013BACKGROUND: It has been considered that repeated episodes of depression can promote cognitive impairment in Alzheimer's disease (AD). However, the biological mechanisms of how depression leads to cognitive impairment are largely unknown. Among different factors leading to depression, it is unclear of how increase in corticosterone leads to neurodegeneration. We hypothesize that corticosterone induces degeneration of synapses and axons in hippocampal neurons so that it promotes cognitive impairment in AD. The goal is to elucidate the pathological changes of synapses and neurites in neurons exposed to …link_to_OA_fulltex