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IC‐P‐109: DNA damage in peripheral blood cells is associated with Alzheimer's disease (AD)‐related plasma proteins in individuals at risk for progression to AD
Author(s) -
Risacher Shan,
Kim Sungeun,
Klaunig James,
Shen Li,
McDonald Brenna,
Farlow Martin,
Ghetti Bernardino,
Gao Sujuan,
Wang Zemin,
Zhou Shaoyu,
Saykin Andrew
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.106
Subject(s) - dna damage , comet assay , oxidative stress , medicine , cognition , neuropsychology , dementia , disease , biomarker , psychology , oncology , clinical psychology , bioinformatics , dna , chemistry , psychiatry , biology , biochemistry
correlations in their thicknesses. Here, we tested that hypothesis among patients with mild AD, patients with amnestic Mild Cognitive Impairment (aMCI), and age-matched healthy controls (HCs). Methods: We recruited 11 patients with AD, 12 with aMCI, and 18 HCs for clinical evaluation and MTL microstructural imaging: On an ultra-high field 7.0-Tesla MRI, we performed an oblique coronal T2-weighted sequence with in-plane resolution of 0.22 mm, permitting direct visual identification and measurement of MTL subfields CA1-SRLM, CA1 pyramidal layer (SP), dentate gyrus (DG)/CA3, and ERC using previously-established manual and semi-automated methods (Kerchner et al., 2012). Results: ERC and CA1-SRLM thicknesses correlated significantly in each of the three cohorts. Among HCs, this correlation was unique, and no other MTL structural covariance emerged. Only in the AD cohort, there was covariance between ERC and CA1-SP. DG/CA3 another synaptic target of ERC did not correlate with ERC in any cohort; only in the aMCI cohort, it correlated with both CA1-SRLM and CA1-SP. Absolute size differences were apparent in all MTL subfields between patients with AD and HCs, but not between patients with aMCI and HCs. As previously reported, delayed memory performance correlates with both ERC and CA1-SRLM thicknesses in mild AD (Kerchner et al., 2012), and we found the same phenomenon among our aMCI cohort but not HCs. Conclusions: ERC and CA1-SRLM two early targets of AD pathology demonstrate structural covariance among older adults regardless of cognitive status. In patients with AD, the cell body layer of CA1 joins in the correlation. A feature that distinguished aMCI and AD patients from HCs was a tight correlation between delayed memory performance and ERC and CA1-SRLM thicknesses, implicating these synaptically-connected, tau-vulnerable MTL subfields with a core symptom of the illness.