Premium
IC‐P‐094: Medial temporal lobe changes preceding symptom onset of mild cognitive impairment: The BIOCARD Cohort
Author(s) -
Miller Michael I.,
Younes Laurent,
Ratnanather John,
Brown Timothy,
Wang MeiCheng,
Lu Yi,
Li Shanshan,
Pettigrew Corinne,
Mori Susumu,
Albert Marilyn
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.091
Subject(s) - entorhinal cortex , temporal lobe , magnetic resonance imaging , atrophy , cohort , medicine , dementia , hippocampus , cardiology , cognitive decline , psychology , neuroscience , disease , radiology , epilepsy
hippocampus, amygdala and bilateral thalamus. In contrast, MCI had faster FA decline than the control group in the limbic regions including bilateral posterior cingulum, right parahippocampal cingulum, left cres of fornix and left uncinate fasciculus, wide spread temporoparietal regions including the bilateral posterior callosal tapetum, bilateral postcentral blades, and a few frontal regions including the right middle frontal blade and the left superior frontooccipital fasciculus.Conclusions: The results demonstrate that MCI is associated with both progressive GM loss andWM degradation over time. The patterns of GM andWMchanges used togethermay improve early detection of AD pathology.