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IC‐P‐085: Early pathological changes due to Alzheimer's disease are detected by graph theoretical measures of functional connectivity
Author(s) -
Brier Matthew,
Thomas Jewell,
Fagan Anne,
Holtzman David,
Benzinger Tammie,
Morris John,
Ances Beau
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.082
Subject(s) - pathological , dementia , clustering coefficient , disease , alzheimer's disease , neuroscience , clinical dementia rating , parkinson's disease , biomarker , psychology , pathology , medicine , cluster analysis , biology , computer science , artificial intelligence , biochemistry
Ab H group.Conclusions:We have employed metabolic connectivity analysis to examine disruptions of the cortical correlation architecture as a function of b-amyloid burden. The aberrant metabolic connections observed in the Ab H group may be a consequence of variable spatio-temporal patterns of compensatory responses and/or cortical remodeling during the early stages of AD. The quantitative approach employed in this study may serve as a powerful, non-invasive imaging biomarker for early diagnosis/prognosis and objective evaluation of the efficacy of novel amyloid-lowering therapeutic agents.