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IC‐P‐070: Evaluation of a radiolabelled butyrylcholinesterase ligand, N‐methyl‐4‐piperdinyl‐4‐[18F]‐fluorobenzoate, in human brain tissues
Author(s) -
Jollymore Courtney,
Macdonald Ian,
Pottie Ian,
Martin Earl,
Darvesh Sultan
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.067
Subject(s) - butyrylcholinesterase , acetylcholinesterase , neuropathology , cholinesterase , cholinergic , alzheimer's disease , acetylcholine , neuroscience , pathology , chemistry , disease , medicine , aché , psychology , biochemistry , enzyme
MMSE1⁄422.962.4). Thresholds were derived separately for ADNI 1.5 T (N1⁄489) and 3T (N1⁄4174) data, and applied separately to UCSF 1.5T and 3T data to compare the sensitivity of HV and TPC across AD variants. Results: HV and TPC performed well in discriminating ADNI NC and AD subjects per MRI field strength (FIGURE). For 1.5T, HV had an area under the ROC curve (AUC)1⁄40.929, sensitivity1⁄490%, and specificity1⁄490%, and for 3T, AUC1⁄40.936, sensitivity1⁄485%, specificity1⁄486%. For TPC: AUC1⁄40.813, sensitivity1⁄482%, and specificity1⁄469% for 1.5T; AUC1⁄40.839, sensitivity1⁄472%, specificity1⁄487% for 3T. Overall, both HV and TPC correctly classified 6/7 UCSF LO-AD subjects (sensitivity1⁄486%). However, HV was poorly sensitive in early-onset and atypical AD variants (overall sensitivity1⁄432%: 6/12 EO-AD, 2/13 lvPPA, 4/13 PCA, FIGURE), while TPC was significantly more sensitive in these patients (overall sensitivity1⁄482%: 10/12 EO-AD, 11/13 lvPPA, 10/13 PCA; c 2(2)1⁄414.4, p<0.001). Conclusions: HVand TPC perform well as neuronal injury biomarkers in late-onset AD. However, TPC is far more sensitive than HV in early-onset and atypical AD and is the preferred MRI biomarker in these populations.