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IC‐P‐069: Temporoparietal cortical thickness outperforms hippocampal volume as a biomarker for atypical and early‐onset Alzheimer's disease
Author(s) -
CohnSheehy Brendan,
Ghosh Pia,
Wirth Miranka,
Lehmann Manja,
Madison Cindee,
Irwin William,
Miller Bruce,
Jagust William,
Rosen Howard,
Rabinovici Gil
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.066
Subject(s) - early onset alzheimer's disease , atrophy , primary progressive aphasia , receiver operating characteristic , dementia , medicine , cardiology , nuclear medicine , alzheimer's disease , psychology , pathology , neuroscience , disease , frontotemporal dementia
tients from normal controls. Plots are separated by MR field strength and region of interest: (A) 1.5Tderived temporoparietal cortical (TPC) thickness; (B) 1.5T-derived hippocampal to intracranial volume ratio (HC/ICV); (C) 3T-derived TPC thickness; and (D) 3T-derived HC/ICV. ADNI subjects were either normal controls (ADNINC) or Alzheimer’s disease patients (ADNI AD). UCSF patients were diagnosed with either late-onset AD (LO-AD), early onset AD (EO-AD), logopenic-variant primary progressive aphasia (1vPPA), or posterior cortical atrophy (PCA). Alzheimer’s Imaging Consortium Poster Presentations: IC-P P41