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IC‐P‐037: Short‐term predictors of clinical progression in the Harvard Aging Brain Study
Author(s) -
Mormino Elizabeth,
Rentz Dorene,
Amariglio Rebecca,
Hedden Trey,
Schultz Aaron,
Ward Andrew,
Marshall Gad,
Chhatwal Jasmeer,
Donovan Nancy,
Papp Kate,
Boot Brendon,
Meneide TamyFey,
Lorius Natacha,
Wigman Sarah,
Younger Alayna,
Betensky Rebecca,
Becker John,
Johnson Keith,
Sperling Reisa
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.038
Subject(s) - clinical dementia rating , logistic regression , medicine , cognitive reserve , dementia , hippocampal formation , cognitive decline , cognition , psychology , cardiology , psychiatry , disease
and NAWM CBF, but not cortical or subcortical GM CBF, were associated with increased age, and hypertension (HTN). CBF measures were not associated with MMSE. NAWM CBF was significantly higher than total WM CBF. After adjusting for age, gender, HTN, and intracranial volume, Greater PV, but not deep, WMH was associated with decreased WM and NAWM CBF; decreased total brain volume was associated with lower cortical CBF; and decreased hippocampal volume was associated with higher subcortical CBF. Conclusions: Regional ASL-derived CBF is associated with brain volume change in nondemented elderly at risk for dementia. The inclusion of ASL with structural MRI may enhance the ability to detect those at risk for cognitive decline, and provide a functional biomarker in prevention and treatment trials aimed at improving cerebral perfusion in the elderly.