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IC‐P‐031: Evaluation of amyloid‐based enrichment using established and novel clinical instruments
Author(s) -
Yu Peng,
Martenyi Ferenc,
Sun Jia,
Siemers Eric,
Schwarz Adam,
Sims John
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.032
Subject(s) - nuclear medicine , posterior cingulate , sample size determination , medicine , amyloid (mycology) , standardized uptake value , positron emission tomography , cortex (anatomy) , psychology , pathology , neuroscience , mathematics , statistics
filter. Results:Demographics are summarized in table 1. [18 F]FDG uptake correlated positively (Figure 1) with RAVLT30 and RAVLTST in the hippocampus of EMCI. Hypometabolism correlated with LM (left hippocampus) in LMCI and with RAVLTST (temporal lobe) in AD. [18 F]AV45 uptake (Figure 2) correlated negatively with LM (temporal and parietal) and RAVLTT (parietal) in controls and with RAVLT30, RAVLTTand RAVLTST in the frontal and parietal lobes of EMCI. For all groups collapsed, all tests correlated with brain hypometabolism and [18 F]AV45 uptake in temporal, parietal and frontal areas. Conclusions: RAVLT30 and RAVLTST convey neurodegeneration in EMCI while LM reflects neurodegeneration in LMCI. LM30 correlates with amyloid deposition only in controls, while RAVLT30, RAVLTT and RAVLTST reflect amyloidosis in EMCI.