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IC‐P‐026: An unusual case of logopenic progressive aphasia associated with corticobasal syndrome
Author(s) -
Jiskoot Lize,
Jong Frank Jan,
Swieten John
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.027
Subject(s) - primary progressive aphasia , posterior cortical atrophy , corticobasal degeneration , frontotemporal dementia , psychology , aphasia , semantic dementia , dementia , apraxia , neuropsychology , atrophy , neuroscience , audiology , pathology , medicine , disease , cognition
nM), we predict a higher binding of [18 F]NAV4694 in post-mortem AD brains. Methods: Controls (CN; age1⁄474.6 6 11.7; n1⁄425) and AD (age1⁄475.3 6 8.6; n1⁄413) human samples (Post-mortem delay: CN1⁄420.79 6 14.51; AD1⁄423.85 6 21.63) containing the prefrontal cortex (PFC), hippocampus (HIP), posterior cingulate cortex (PCC), inferior parietal cortex (IPC) and striatum (ST) were acquired from the Douglas Hospital Brain Bank/Canada. Slices were classified according to the CERAD criteria. For autoradiography, we incubated frozen slices (20 mm thick) during 2 hours using [18 F] NAV4694 (specific activity 60 Ci/mmol) and [11 C] PIB (302 Ci/mmol). The imaging plates were scanned using BAS5000 (Fuji-Film). The image outcome measure was the total binding obtained in the same tissue region. Results: [11 C]PIB showed increased binding in AD brains compared to CN brains [PFC (p1⁄40.0001); PCC(p1⁄40.0037); and IPC (p1⁄40.0001)]. However, it failed to detect amyloid plaques in the hippocampus (p1⁄40.0798). [18 F]NAV4694 was capable to differentiate CN from AD in all brain regions studied (PFC, p1⁄40.0001; HIP, p1⁄40.0001; PCC, p1⁄40.0001; and IPC, p1⁄40.0001). No difference was found in ST. Dynamic rangewas higher for [18 F]NAV4694 than [11 C]PIB (11.10 vs. 8.2 z-scores; p1⁄40.04). Assuming z-score of 2 as cutoff value, chi-square showed high confidence between observed and expected to [18 F]NAV4694 (c 2 1⁄42.654; p1⁄40.9151) but significantly discrepancy to [11 C]PIB (c 2 1⁄421.477; p1⁄40.003). Conclusions: Despite molecular similarities, [18 F] NAV4694 better differentiated CN and AD post-mortem brains than [11 C]PIB. Especially, only [18 F]NAV4694 was capable of detect groups differences in hippocampus, a region susceptible to amyloid aggregation. Also, [18 F]NAV4694 presented a wider dynamic range compared to [11 C]PIB. Finally, [18 F]NAV4694 showed less false negative than [11 C]PIB.Our study indicated that [18 F]NAV4694 represent a promising amyloid agent for potential application in AD research and clinical approach.