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IC‐P‐022: The impact of beta‐amyloid deposition and vascular risk factors on cortical thickness and cognition
Author(s) -
Villeneuve Sylvia,
Reed Bruce,
Madison Cindee,
Wirth Miranka,
Kriger Stephen,
Haase Claudi M.,
Marchant Natalie,
DeCarli Charles S.,
Chui Helena,
Weiner Michael,
Jagust William
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.023
Subject(s) - medicine , cardiology , diabetes mellitus , framingham risk score , risk factor , cognitive decline , cholesterol , psychology , endocrinology , dementia , disease
(ADNI) subjects with available [11 C] PIB and peripheral blood protein data. MRI-coregistered PET data was smoothed with a 15 mm kernel and convected onto the 3D hemispheric models along the warping deformations computed in cortical pattern matching of the associated MRI scans. We applied linear regression to examine in 3D the associations between apolipoprotein E (ApoE), apolipoprotein J (ApoJ), brain-derived neurotrophic factor (BDNF), interleukin 6 receptor (IL6R), interleukin 13 (IL13) and tumor-necrosis factor a (TNF a) and PIB SUVR, while adjusting for age and sex. We used permutation statistics thresholded at p<0.01, for multiple comparisons correction.Results: Plasma ApoE showed significant negative association with PIB SUVR throughout the brain, except in the sensorimotor and entorhinal cortex (left p corrected 1⁄40.004, right p corrected 1⁄40.008). Plasma BDNF levels showed significant negative associations with left greater than right amyloid burden in the lateral temporal, inferior parietal, inferior frontal, anterior and posterior cingulate, and orbitofrontal regions (left p corrected1⁄40.03). ApoJ, IL6R, IL13 and TNF a failed to show significant associations with PIB SUVR. Conclusions: Lower peripheral blood levels of proteins that are involved in A b degradation and clearance (ApoE) and neuroprotection against A b toxicity (BDNF) showed a significant widespread association with severity of brain amyloidosis. This further establishes the role of these two proteins in AD. The lack of association between IL6R, IL13 and TNF a may be explained by their stronger relevance to the neuroinflammatory aspects of AD, which are not directly measured by amyloid imaging.