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IC‐P‐019: In vivo Gd‐staining MRI reveals efficacy of anti‐beta‐amyloid immunotherapy after longitudinal study in a transgenic mouse model of Alzheimer's disease
Author(s) -
Santin Mathieu,
Debeir Thomas,
Delzescaux Thierry,
Hérard AnneSophie,
Cohen Caroline,
Pradier Laurent,
Rooney Thomas,
Dhenain Marc
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.020
Subject(s) - genetically modified mouse , antibody , in vivo , medicine , pathology , staining , magnetic resonance imaging , immunohistochemistry , amyloid (mycology) , transgene , chemistry , immunology , biology , biochemistry , microbiology and biotechnology , gene , radiology
of cognition by committee (n1⁄477 normal and n1⁄415 MCI). Results: Nearly half (44/92) of non-demented older adults in this sub-study were PiB+ for amyloid. Amyloid deposition was associated with ba PWVand SBP. After adjustment for covariates, one standard deviation increase in ba PWV resulted in nearly a 2-fold increase in the odds of being PiB+. Additional adjustment for ApoE-4, mild cognitive impairment and SBP did not attenuate this association. HigherWMHvolumewas associated with increased central PWV (cf PWV (p<0.01) and hf PWV (p1⁄40.03)) and SBP (p1⁄40.05). Each standard deviation increase in ba PWV and cf PWV was associated with a 3 and 4-fold increase, respectively, in the odds of having both high amyloid and high WMH, relative to low amyloid and lowWMH. Conclusions: This is the first study to show that PWV is associated with PiB-PET. Our results confirm initial reports showing associations between SBP and PiB-PETand extend this research by showing arterial stiffness is associated with in vivo amyloid deposition in non-demented individuals, independent of SBP and anti-hypertensive medication use. It will be important to determine if the prevention of elevated BP and vascular stiffness at middle-age will reduce amyloid deposition in the aging brain.