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IC‐P‐012: Differential impact of amyloidosis and tau pathology on brain metabolism
Author(s) -
Cheewakriengkrai Laksanun,
Rowley Jared,
Mohades Sara,
Beaudry Thomas,
Leuzy Antoine,
Fonov Vladimir,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.013
Subject(s) - amyloidosis , pathology , standardized uptake value , voxel , medicine , correlation , amyloid (mycology) , nuclear medicine , positron emission tomography , neuroscience , psychology , mathematics , radiology , geometry
a small cluster in the frontal area. In contrast, CSF t-tau or p-tau showed correlation with [18F]florbetapir in frontal, temporal and parietal brain regions. No correlation was shown between global [18F]FDGSUVR and the binding of amyloid imaging agents (Figure1). Conclusions: The pattern of regional deposition of fibrillary amyloid in the brain is non-linearly associated with CSF Ab1-42 concentrations. However the link between p-tau, t-tau and fibrillary amyloid deposition seems to be dependent on the amyloid-imaging agent. While imaging and CSF measures of amyloid pathology are equivalent, [18F]FDG uptake seems to provide independent information from regional deposition of fibrillary amyloid.