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IC‐P‐004: Biomarker‐based prediction of cognitive decline in 270 nondemented older individuals: Three‐year follow‐up results from the Australian Imaging Biomarkers and Lifestyle Study of Aging (AIBL)
Author(s) -
Rowe Christopher,
Ames David,
Ellis Kathryn,
Bourgeat Pierrick,
Brown Belinda,
Salvado Olivier,
Szoeke Cassandra,
Woodward Michael,
Macaulay Lance,
Maruff Paul,
Martins Ralph,
Masters Colin,
Villemagne Victor
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.05.005
Subject(s) - dementia , medicine , biomarker , cognitive decline , oncology , gerontology , psychology , odds ratio , disease , biology , biochemistry
The mean absolute difference was higher for AD (15%) than for MCI (11%) or NC (8%). Based on a cut-off value of 1.4, the rate of misclassification between PiB-positive and negative was 3.1% at baseline, 3.6% at 18 months and 2.6% at 36 months.Conclusions: The automatic PET quantification obtained a good correlation with manual measurements, especially in subjects with low neocortical SUVR. The rate of misclassification between PiB positive and negative was low enough to make it potentially suitable for use in clinical settings. IC-P-004 BIOMARKER-BASED PREDICTION OF COGNITIVE DECLINE IN 270 NONDEMENTED OLDER INDIVIDUALS: THREE-YEAR FOLLOWUP RESULTS FROM THE AUSTRALIAN IMAGING BIOMARKERS ANDLIFESTYLE STUDYOFAGING (AIBL) Christopher Rowe, David Ames, Kathryn Ellis, Pierrick Bourgeat, Belinda Brown, Olivier Salvado, Cassandra Szoeke, Michael Woodward, Lance Macaulay, Paul Maruff, Ralph Martins, Colin Masters, Victor Villemagne, Austin Hospital, Melbourne, Australia; National Ageing Research Institute Inc. (NARI), Parkville, Australia; St. Georges Hospital, Kew, Australia; CSIRO, Herston, Australia; Edith Cowan University, Perth, WA, Australia; CSIRO, Brisbane, Australia; National Ageing Research Institute Inc. (NARI), Melbourne, Australia; Austin Health, Heidelberg West, Australia; CSIRO, Parkville, Australia; CogState Ltd, Melbourne, Australia; Edith Cowan University, Perth, Australia; University of Melbourne, Melbourne, VIC, Australia; Austin Health, Melbourne, Australia. Contact e-mail: christopher.rowe@austin.org.au