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Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment
Author(s) -
Liu Jie,
Zhu YongSheng,
Khan Muhammad Ayaz,
Brunk Estee,
MartinCook Kristin,
Weiner Myron F.,
Cullum C. Munro,
Lu Hanzhang,
Levine Benjamin D.,
DiazArrastia Ramon,
Zhang Rong
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.507
Subject(s) - cerebral blood volume , cardiology , cerebral blood flow , perfusion , medicine , cerebral perfusion pressure , cerebral hypoperfusion , oxygenation , cognitive impairment , disease
Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty‐two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO 2 ), and brain tissue volume were measured using color‐coded duplex ultrasonography (CDUS), near‐infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO 2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO 2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low‐cost and bedside‐available CDUS and NIRS technology.