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O4–09–06: Longitudinal gray matter loss and diffusion anisotropy changes in mild cognitive impairment
Author(s) -
Zhang Yu,
Schuff Norbert,
Buckley Shan,
Chao Linda,
Yaffe Kristine,
Weiner Michael
Publication year - 2013
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2013.04.388
Subject(s) - fractional anisotropy , white matter , diffusion mri , magnetic resonance imaging , brain size , nuclear medicine , psychology , audiology , medicine , radiology
affected by WMH was not associated with cognition. Conclusions: These findings highlight that beta-amyloid deposition and white matter alterations differentially contribute to changes in brain structure and cognition among cognitively normal older adults, while implicating that aging-related structural and cognitive changes involve multiple factors beyond beta-amyloid and cerebrovascular pathologies.